Virtualization on x86_64 is since 2019 (or short after [0]) in principle kernel independent. So, Vbox6 and Seoul should be runnable on all modern kernels. Well, why I say “should” or “principle” ? We don’t test all possible variations manually (man power, interest), so I think you should expect issues.
As Seoul maintainer I can only say, that it works for me on my Intel notebook and AMD desktop (Ryzen 5700) quite well for -nova-.